CSNK1G2 Gene Summary [Human]
Enables protein serine/threonine kinase activity. Involved in peptidyl-serine phosphorylation. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CSNK1G2 |
| Official Name | casein kinase 1 gamma 2 [Source:HGNC Symbol;Acc:HGNC:2455] |
| Ensembl ID | ENSG00000133275 |
| Bio databases IDs | |
| Aliases | casein kinase 1 gamma 2 |
| Synonyms | 2810429I12Rik, AI463719, casein kinase 1 gamma 2, casein kinase 1, gamma 2, casein kinase 1 γ 2, casein kinase 1, γ 2, CK1g2, CK1 gamma 2, CK1 γ 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CSNK1G2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Casein kinase 1 gamma C terminal
- centaurin alpha 1 domain
- kinase domain
- protein serine/threonine kinase
- Protein Kinases, catalytic domain
- protein binding
- prenylation site
Pathways
Biological processes and signaling networks where the CSNK1G2 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Gap Junction Signaling
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NFAT in Regulation of the Immune Response
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- periodontitis
- metabolic syndrome X
- coronary artery disease
- lymphomagenesis
- primary central nervous system lymphoma
- primary cancer
- central nervous system cancer
role in cell
- phosphorylation in
- activation in
- stabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CSNK1G2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- positive regulation of canonical Wnt receptor signaling pathway
- Wnt receptor signaling pathway
- protein phosphorylation
- endocytosis
- peptidyl-serine phosphorylation
- sphingolipid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cell cortex
- membrane
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein serine/threonine kinase activity