PGLYRP3 Gene Summary [Human]
This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. These proteins are part of the innate immune system and recognize peptidoglycan, a ubiquitous component of bacterial cell walls. This antimicrobial protein binds to murein peptidoglycans of Gram-positive bacteria. [provided by RefSeq, Oct 2014]
Details
| Type | Protein Coding |
| Official Symbol | PGLYRP3 |
| Official Name | peptidoglycan recognition protein 3 [Source:HGNC Symbol;Acc:HGNC:30014] |
| Ensembl ID | ENSG00000159527 |
| Bio databases IDs | |
| Aliases | peptidoglycan recognition protein 3, peptidoglycan recognition protein I alpha precursor |
| Synonyms | peptidoglycan recognition protein 3, Pglyrp3b, PGLYRPIALPHA, PGRPIA, PGRP-Ialpha |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PGLYRP3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- N-acetylmuramoyl-L-alanine amidase
- peptidoglycan binding
- protein binding
- peptidoglycan recognition
- transmembrane receptor
- PGRP
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Extracellular Space
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PGLYRP3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidoglycan catabolic process
- negative regulation of natural killer cell differentiation involved in immune response
- innate immune response
- killing of cells of other organism
- detection of bacterium
- negative regulation of interferon-gamma production
- interaction with host
- defense response to Gram-positive bacterium
Cellular Component
Where in the cell the gene product is active
- membrane
- macromolecular complex
- extracellular region
Molecular Function
What the gene product does at the molecular level
- peptidoglycan binding
- peptidoglycan receptor activity
- zinc ion binding
- protein binding
- protein heterodimerization activity
- N-acetylmuramoyl-L-alanine amidase activity