UBQLN4 Gene Summary [Human]
Enables K48-linked polyubiquitin modification-dependent protein binding activity and identical protein binding activity. Involved in cellular response to DNA damage stimulus; negative regulation of double-strand break repair via homologous recombination; and regulation of cellular catabolic process. Located in several cellular components, including autophagosome; nucleoplasm; and site of DNA damage. Part of protein-containing complex. Colocalizes with cytosolic proteasome complex and nuclear proteasome complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | UBQLN4 |
| Official Name | ubiquilin 4 [Source:HGNC Symbol;Acc:HGNC:1237] |
| Ensembl ID | ENSG00000160803 |
| Bio databases IDs | |
| Aliases | ubiquilin 4, ataxin-1 ubiquitin-like interacting protein |
| Synonyms | A1U, A1Up, C1orf6, CIP75, RGD1308273, UBIN, ubiquilin 4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human UBQLN4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- Ubiquitin family
- UV excision repair protein Rad23
- Ubl1_cv_Nsp3_N-like
- Ubiquitin homologues
- protein binding
- STI1 domain
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- rectum cancer
- organismal death
- transitional cell bladder cancer
- prostate cancer
- urothelial bladder carcinoma
- prostatic adenocarcinoma
- endometrial adenocarcinoma
- endometrial adenocarcinoma formation
- epithelial cancer
regulates
role in cell
- DNA damage response
- maturation
- replication in
- hypophosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- nucleoplasm
- autophagic vacuoles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human UBQLN4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- negative regulation of double-strand break repair via homologous recombination
- autophagy
- response to DNA damage stimulus
- regulation of proteasomal ubiquitin-dependent protein catabolic process
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- cytoplasmic vesicle
- cytosol
- cytosolic proteasome complex
- macromolecular complex
- nuclear proteasome complex
- autophagic vacuole
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- polyubiquitin binding