RNF11 Gene Summary [Human]
The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN). [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | RNF11 |
| Official Name | ring finger protein 11 [Source:HGNC Symbol;Acc:HGNC:10056] |
| Ensembl ID | ENSG00000123091 |
| Bio databases IDs | |
| Aliases | ring finger protein 11 |
| Synonyms | CGI-123, LOC683019, LOC683844, N4wbp2, ring finger protein 11, Rnf11l1, SID1669 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RNF11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- acidic-cluster dileucine motif
- ubiquitin protein ligase activity
- enzyme
- Ring finger domain
- protein binding
- proline tyrosine motif
- RING-like zinc finger
- DNA binding
- zinc ion binding
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
role in cell
- expression in
- proliferation
- activation in
- migration
- binding in
- ubiquitination in
- stabilization in
- JG-231 resistance
- TAK-901 resistance
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RNF11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ubiquitin-dependent protein catabolic process
- protein autoubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- early endosome
- extracellular vesicular exosome
- ubiquitin ligase complex
- recycling endosome
Molecular Function
What the gene product does at the molecular level
- DNA binding
- zinc ion binding
- protein binding