MYDGF Gene Summary [Human]
The protein encoded by this gene was previously thought to support proliferation of lymphoid cells and was considered an interleukin. However, this activity has not been reproducible and the function of this protein is currently unknown. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | MYDGF |
| Official Name | myeloid derived growth factor [Source:HGNC Symbol;Acc:HGNC:16948] |
| Ensembl ID | ENSG00000074842 |
| Bio databases IDs | |
| Aliases | myeloid derived growth factor |
| Synonyms | C19orf10, D17Wsu104e, EUROIMAGE1875335, IL25, IL27, IL27w, Ly6elg, myeloid-derived growth factor, R33729 1, SF20 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MYDGF often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UPF0556 domain
- protein binding
- cytokine
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- weight loss
- systolic dysfunction
role in cell
- proliferation
- phosphorylation in
- apoptosis
- differentiation
- production in
- osteoclastogenesis
- expansion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi Apparatus
- Endoplasmic Reticulum
- endoplasmic reticulum lumen
- nuclear rim
- Golgi vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MYDGF gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- angiogenesis
- negative regulation of apoptotic process
- apoptotic process
- positive regulation of protein phosphorylation
- positive regulation of endothelial cell proliferation
- positive regulation of MAPK cascade
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of angiogenesis
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- endoplasmic reticulum
- Golgi apparatus
- endoplasmic reticulum-Golgi intermediate compartment
Molecular Function
What the gene product does at the molecular level
- protein binding