Ubqln4 Gene Summary [Mouse]
Predicted to enable K48-linked polyubiquitin modification-dependent protein binding activity and identical protein binding activity. Predicted to be involved in several processes, including negative regulation of double-strand break repair via homologous recombination; regulation of catabolic process; and ubiquitin-dependent protein catabolic process. Located in cytosol and endoplasmic reticulum membrane. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human UBQLN4 (ubiquilin 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ubqln4 |
| Official Name | ubiquilin 4 [Source:MGI Symbol;Acc:MGI:2150152] |
| Ensembl ID | ENSMUSG00000008604 |
| Bio databases IDs | |
| Aliases | ubiquilin 4 |
| Synonyms | A1U, A1Up, C1orf6, CIP75, RGD1308273, UBIN, ubiquilin 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ubqln4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- Ubiquitin family
- UV excision repair protein Rad23
- Ubl1_cv_Nsp3_N-like
- Ubiquitin homologues
- protein binding
- STI1 domain
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- rectum cancer
- organismal death
- transitional cell bladder cancer
- prostate cancer
- urothelial bladder carcinoma
- prostatic adenocarcinoma
- endometrial adenocarcinoma
- endometrial adenocarcinoma formation
- epithelial cancer
regulates
role in cell
- DNA damage response
- maturation
- replication in
- hypophosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- nucleoplasm
- autophagic vacuoles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ubqln4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- negative regulation of double-strand break repair via homologous recombination
- autophagy
- response to DNA damage stimulus
- regulation of proteasomal ubiquitin-dependent protein catabolic process
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- cytoplasmic vesicle
- cytosol
- cytosolic proteasome complex
- macromolecular complex
- nuclear proteasome complex
- autophagic vacuole
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- polyubiquitin binding