ALKBH4 Gene Summary [Human]
Enables 2-oxoglutarate-dependent dioxygenase activity and actin binding activity. Involved in actomyosin structure organization; cleavage furrow ingression; and protein demethylation. Located in contractile ring and midbody. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ALKBH4 |
| Official Name | alkB homolog 4, lysine demethylase [Source:HGNC Symbol;Acc:HGNC:21900] |
| Ensembl ID | ENSG00000160993 |
| Bio databases IDs | |
| Aliases | alkB homolog 4, lysine demethylase |
| Synonyms | 2010004B12Rik, ABH4, Abj4, alkB homolog 4, lysine demethylase, RGD1308608 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ALKBH4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 2-oxoglutarate:oxygen oxidoreductase
- actin binding
- demethylase activity
- enzyme
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- contractile rings
- midbody
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ALKBH4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of gene expression, epigenetic
- protein demethylation
- actomyosin structure organization
- demethylation
- cleavage furrow ingression
Cellular Component
Where in the cell the gene product is active
- contractile ring
- cytoplasm
- midbody
- nucleolus
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding
- oxidoreductase activity
- demethylase activity
- metal ion binding
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
- oxidative DNA demethylase activity