LRWD1 Gene Summary [Human]
The protein encoded by this gene interacts with components of the origin recognition complex (ORC) and regulates the formation of the prereplicative complex. The encoded protein stabilizes the ORC and therefore aids in DNA replication. This protein is required for the G1/S phase transition of the cell cycle. In addition, the encoded protein binds to trimethylated histone H3 in heterochromatin and recruits the ORC and lysine methyltransferases, which help maintain the repressive heterochromatic state. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Details
| Type | Protein Coding |
| Official Symbol | LRWD1 |
| Official Name | leucine rich repeats and WD repeat domain containing 1 [Source:HGNC Symbol;Acc:HGNC:21769] |
| Ensembl ID | ENSG00000161036 |
| Bio databases IDs | |
| Aliases | leucine rich repeats and WD repeat domain containing 1, origin recognition complex associated, centromere protein 33 |
| Synonyms | 1200011O22Rik, CENP-33, leucine-rich repeats and WD repeat domain containing 1, ORCA |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LRWD1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine-rich repeats, outliers
- Leucine-rich repeats, typical (most populated) subfamily
- histone binding
- protein binding activity, bridging
- Leucine rich repeat
- WD domain, G-beta repeat
- chromatin binding
- WD40
- protein binding
- Leucine Rich repeats (2 copies)
- leucine-rich repeat
- WD40 repeats
- methyl-CpG binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- heterochromatic focus
- intracellular membrane-bounded organelle
- telomeric heterochromatin
- nuclear foci
- nucleoplasm
- nucleoli
- kinetochores
- centromeres
- telomeres
- centromeric heterochromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LRWD1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA-dependent DNA replication initiation
- establishment of protein localization to chromatin
- chromatin organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome, telomeric region
- centrosome
- cytoplasm
- intracellular membrane-bounded organelle
- kinetochore
- nucleolus
- nuclear origin of replication recognition complex
- centromeric heterochromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- methylated histone residue binding
- chromatin binding
- methyl-CpG binding