EIF3C Gene Summary [Human]
Enables ribosome binding activity. Contributes to translation initiation factor activity. Involved in positive regulation of mRNA binding activity; positive regulation of translation; and translational initiation. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | EIF3C |
| Official Name | eukaryotic translation initiation factor 3 subunit C [Source:HGNC Symbol;Acc:HGNC:3279] |
| Ensembl ID | ENSG00000184110 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 3 subunit C |
| Synonyms | 3230401O13RIK, EIF3CL, eIF3-p110, EIF3S8, eukaryotic translation initiation factor 3 subunit C |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EIF3C often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
- ribosome binding
- translation initiation factor
- protein binding
- translation regulator
- Eukaryotic translation initiation factor 3 subunit 8 N-terminus
Pathways
Biological processes and signaling networks where the EIF3C gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- postmenopausal osteoporosis
- testicular seminoma
- seminomatous testicular cancer
- Rett syndrome
- systemic autoimmune syndrome
role in cell
- proliferation
- production in
- invasion by
- cell viability
- apoptosis
- growth
- migration
- phosphorylation in
- synthesis in
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human EIF3C gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of translation
- formation of translation initiation complex
- translational initiation
Cellular Component
Where in the cell the gene product is active
- eukaryotic 43S preinitiation complex
- cytosol
- eukaryotic 48S preinitiation complex
- eukaryotic translation initiation factor 3 complex
Molecular Function
What the gene product does at the molecular level
- translation initiation factor activity
- protein binding
- RNA binding
- ribosome binding
- translation initiation factor binding