TREML1 Gene Summary [Human]
This gene encodes a member of the triggering receptor expressed on myeloid cells-like (TREM) family. The encoded protein is a type 1 single Ig domain orphan receptor localized to the alpha-granule membranes of platelets. The encoded protein is involved in platelet aggregation, inflammation, and cellular activation and has been linked to Gray platelet syndrome. Alternative splicing results in multiple transcript variants [provided by RefSeq, Nov 2012]
Details
| Type | Protein Coding |
| Official Symbol | TREML1 |
| Official Name | triggering receptor expressed on myeloid cells like 1 [Source:HGNC Symbol;Acc:HGNC:20434] |
| Ensembl ID | ENSG00000161911 |
| Bio databases IDs | |
| Aliases | triggering receptor expressed on myeloid cells like 1, TREM-like transcript 1 |
| Synonyms | dJ238O23.3, GLTL1825, PRO3438, RGD1565175, TLT-1, triggering receptor expressed on myeloid cells-like 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TREML1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- immunoreceptor tyrosine-based inhibition motif
- immunoglobulin domain
- Immunoglobulin like
- protein binding
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- cell surface
- Plasma Membrane
- Golgi Apparatus
- cytosol
- nuclear speckles
- alpha granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TREML1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- innate immune response
- platelet activation
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule
- nuclear speck
- membrane
- cytosol
- Golgi apparatus
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- transmembrane signaling receptor activity