EZR
EZR Gene Summary
The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | EZR |
| Official Name | ezrin [Source:HGNC Symbol;Acc:HGNC:12691] |
| Ensembl ID | ENSG00000092820 |
| Bio databases IDs | |
| Aliases | ezrin, cytovillin 2 |
| Synonyms | CVIL,CVL,Cytovillin2,EZRIN,HEL-S-105,p81,VIL2 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ermad domain
- membrane-association domain
- cell adhesion molecule binding
- identical protein binding
- proline rich domain
- ERM binding domain
- FERM subdomain f3
- FERM subdomain f2
- FERM domain
- Vacuolar (H+)-ATPase G subunit
- actin binding
- FERM domain B-lobe
- FERM central domain
- Band 4.1 homologues
- phosphatidylinositol 4,5-biphosphate binding domain
- protein kinase A binding
- protein kinase binding
- Ezrin/radixin/moesin, alpha-helical domain
- alpha helix
- protein domain specific binding
- protein binding
- Pleckstrin homology-like domain
- FERM N-terminal domain
- phosphorylation site
- actin filament binding
- microtubule binding
- ATPase binding
- actin-binding domain
- F-actin binding domain
- binding protein
- MAP7 (E-MAP-115) family
- Ubl1_cv_Nsp3_N-like
- cytosolic tail domain
- Ezrin/radixin/moesin family C terminal
- structural molecule
- FERM C-terminal PH-like domain
- Fas binding domain
Pathways
Biological processes and signaling networks where the EZR gene plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Agranulocyte Adhesion and Diapedesis
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- Granulocyte Adhesion and Diapedesis
- Leukocyte Extravasation Signaling
- Regulation of Cellular Mechanics by Calpain Protease
- RhoA Signaling
- RhoGDI Signaling
- Signaling by Rho Family GTPases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- NF2
- TNIP1
- TIPARP
- ERBIN
- MAPT
- CBL
- TDRD3
- CYLD
- MARK2
- CTNNB1
disease
- neoplasia
- epithelial cancer
- epithelial neoplasia
- cancer
- metastasis
- splenomegaly
- Huntington disease
- breast cancer
- amyotrophic lateral sclerosis
- advanced cancer
regulated by
- hydrogen peroxide
- estradiol-17beta-benzoate
- ERK1/2
- forskolin
- progesterone
- dexamethasone
- insulin
- cytochalasin D
- FOS
- IL1B
regulates
- RPS6KB1
- AKT
- NFAT (family)
- ATF4
- PTGS2
- IL1B
- TNF
- DDIT4
- PI3K (complex)
- Ca2+
role in cell
- expression in
- apoptosis
- activation in
- degradation in
- phosphorylation in
- proliferation
- growth
- production in
- quantity
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- myelin enriched fraction
- raft fractions
- detergent-insoluble fractions
- membrane fraction
- cytoskeletal membrane fractions
- docking structure
- fibrillar center
- perinodal process
- cortical cytoskeleton
- ruffle
- Cytoplasm
- invadopodia
- cilia
- cell surface
- cell periphery
- intracellular space
- apical compartment
- perinuclear region
- cellular membrane
- focal adhesions
- actin cytoskeleton
- Nucleus
- basal bodies
- endosomes
- actin filaments
- immunological synapses
- cell-cell contacts
- cytosol
- apical cytoplasm
- stereocilia
- apical cell surfaces
- basolateral cell surfaces
- cytoplasmic face of plasma membrane
- membrane ruffles
- apical membrane
- uropod
- plasma membrane projections
- basolateral membrane
- nuclear envelope
- nuclear speckles
- nodes of Ranvier
- growth cone
- outer mesaxons
- glial cell projections
- Z line
- apical vacuoles
- transverse tubules
- apical cell-cell contacts
- cell tip
- membrane rafts
- brush border
- cleavage furrow
- membrane tufts
- cellular protrusions
- membrane processes
- microvilli
- filopodia
- cell membrane leading edge
- perikaryon
- axons
- astrocyte projections
- exosomes
- phagosomes
- lamellipodia
- microspikes
- apical processes
- detergent-soluble fraction
- cytoskeletal fraction
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the EZR gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- regulation of cell shape
- regulation of cell size
- cortical microtubule organization
- sphingosine-1-phosphate signaling pathway
- leukocyte cell-cell adhesion
- positive regulation of multicellular organism growth
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of interleukin-2 production
- establishment of centrosome localization
- establishment of epithelial cell apical/basal polarity
- protein kinase A signaling cascade
- gland morphogenesis
- positive regulation of protein catabolic process
- membrane to membrane docking
- filopodium assembly
- establishment of endothelial barrier
- astral microtubule organization
- intestinal D-glucose absorption
- protein complex localization
- regulation of actin cytoskeleton organization
- negative regulation of T cell receptor signaling pathway
- protein localization to cell cortex
- negative regulation of ERK1 and ERK2 cascade
- positive regulation of gene expression
- cellular response to cAMP
- microvillus assembly
- regulation of microvillus length
- positive regulation of early endosome to late endosome transport
- receptor internalization
- actin cytoskeleton organization
- actin filament bundle assembly
- protein localization in plasma membrane
CELLULAR COMPONENT
Where in the cell the gene product is active
- cell projection
- fibrillar center
- immunological synapse
- endosome
- extracellular vesicular exosome
- apical part of cell
- focal adhesion
- brush border
- microvillus
- ruffle
- actin cytoskeleton
- cytosol
- ruffle membrane
- cortical cytoskeleton
- cilium basal body
- actin filament
- plasma membrane
- microvillus membrane
- adherens junction
- extracellular space
- perinuclear region of cytoplasm
- uropod
- cytoplasm
- membrane
- filopodium
- vesicle
- macromolecular complex
- basolateral plasma membrane
- apical plasma membrane
- cell periphery
MOLECULAR FUNCTION
What the gene product does at the molecular level
- identical protein binding
- protein domain specific binding
- cell adhesion molecule binding
- S100 protein binding
- microtubule binding
- actin filament binding
- RNA binding
- protein binding
- actin binding
- cadherin binding
- protein kinase A regulatory subunit binding
- protein kinase A catalytic subunit binding
- protein kinase A binding
- ATPase binding