ZNF653 Gene Summary [Human]
Enables AF-2 domain binding activity and transcription corepressor activity. Involved in extracellular negative regulation of signal transduction and negative regulation of nucleic acid-templated transcription. Predicted to be located in extracellular region. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ZNF653 |
| Official Name | zinc finger protein 653 [Source:HGNC Symbol;Acc:HGNC:25196] |
| Ensembl ID | ENSG00000161914 |
| Bio databases IDs | |
| Aliases | zinc finger protein 653 |
| Synonyms | E430039K05Rik, RGD1308754, Zfp653, zinc finger protein 653, zinc finger protein Zip67, ZIP67 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZNF653 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- zinc finger
- transcription regulator
- AF-2 domain binding
- Zinc-finger double domain
- transcription co-repressor
- transcription factor binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZNF653 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- extracellular negative regulation of signal transduction
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular region
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- transcription cofactor activity
- metal ion binding
- transcription corepressor activity
- AF-2 domain binding