POP1 Gene Summary [Human]
This gene encodes the protein subunit of two different small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is a ribonuclease that localizes to the nucleus and functions in pre-RNA processing. This protein is also an autoantigen in patients suffering from connective tissue diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
Details
| Type | Protein Coding |
| Official Symbol | POP1 |
| Official Name | POP1 homolog, ribonuclease P/MRP subunit [Source:HGNC Symbol;Acc:HGNC:30129] |
| Ensembl ID | ENSG00000104356 |
| Bio databases IDs | |
| Aliases | POP1 homolog, ribonuclease P/MRP subunit, processing of precursors 1 |
| Synonyms | 4932434G09Rik, ANXD2, POP1 homolog, ribonuclease P/MRP subunit, processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae) |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human POP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ribonuclease P
- Ribonucleases P/MRP protein subunit POP1
- enzyme
- protein binding
- POPLD (NUC188) domain
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleolar region
- metaphase plate
- nucleoplasm
- nucleolus derived foci
- nucleoli
- mitotic spindle
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human POP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA processing
- tRNA catabolic process
- tRNA 5'-leader removal
Cellular Component
Where in the cell the gene product is active
- extracellular space
- ribonuclease MRP complex
- multimeric ribonuclease P complex
- nucleolus
- nucleolar ribonuclease P complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ribonuclease P activity
- protein binding
- RNA binding
- ribonuclease P RNA binding