DRAXIN Gene Summary [Human]
Predicted to be involved in negative regulation of canonical Wnt signaling pathway; negative regulation of neuron projection development; and nervous system development. Predicted to act upstream of or within negative regulation of axon extension and negative regulation of neuron apoptotic process. Predicted to be active in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | DRAXIN |
| Official Name | dorsal inhibitory axon guidance protein [Source:HGNC Symbol;Acc:HGNC:25054] |
| Ensembl ID | ENSG00000162490 |
| Bio databases IDs | |
| Aliases | dorsal inhibitory axon guidance protein, dorsal repulsive axon guidance protein, neural tissue-specific cysteine-rich protein |
| Synonyms | 2610109H07Rik, AGPA3119, C1orf187, dorsal inhibitory axon guidance protein, LOC100044686, LOC686619, neucrin, UNQ3119 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DRAXIN often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Draxin
- protein binding
Pathways
Biological processes and signaling networks where the DRAXIN gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DRAXIN gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- forebrain development
- negative regulation of axon extension
- dorsal spinal cord development
- commissural neuron differentiation in spinal cord
- axon guidance
- Wnt receptor signaling pathway
- anterior commissure morphogenesis
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- binding, bridging