Draxin Gene Summary [Mouse]

Predicted to enable molecular adaptor activity. Involved in negative regulation of canonical Wnt signaling pathway; negative regulation of neuron projection development; and nervous system development. Acts upstream of or within negative regulation of axon extension and negative regulation of hippocampal neuron apoptotic process. Located in extracellular region. Is expressed in several structures, including central nervous system; dorsal root ganglion; future brain; neural retina; and vibrissa. Orthologous to human DRAXIN (dorsal inhibitory axon guidance protein). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Draxin
Official Name
dorsal inhibitory axon guidance protein [Source:MGI Symbol;Acc:MGI:1917683]
Ensembl ID
ENSMUSG00000029005
Bio databases IDs NCBI: 70433 Ensembl: ENSMUSG00000029005
Aliases dorsal inhibitory axon guidance protein
Synonyms 2610109H07Rik, AGPA3119, C1orf187, dorsal inhibitory axon guidance protein, LOC100044686, LOC686619, neucrin, UNQ3119
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Draxin often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Draxin
  • protein binding

Pathways

Biological processes and signaling networks where the Draxin gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • obsessive-compulsive disorder
  • agenesis of corpus callosum
regulated by
regulates
role in cell
  • apoptosis
  • differentiation
  • proliferation
  • invasion by
  • development
  • extension
  • guidance

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Extracellular Space

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Draxin gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • negative regulation of canonical Wnt receptor signaling pathway
  • forebrain development
  • negative regulation of axon extension
  • dorsal spinal cord development
  • commissural neuron differentiation in spinal cord
  • axon guidance
  • Wnt receptor signaling pathway
  • anterior commissure morphogenesis

Cellular Component

Where in the cell the gene product is active
  • extracellular region

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • binding, bridging

Gene-Specific Assays for Results You Can Trust

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