SDC3 Gene Summary [Human]
The protein encoded by this gene belongs to the syndecan proteoglycan family. It may play a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism. Allelic variants of this gene have been associated with obesity. [provided by RefSeq, Oct 2009]
Details
| Type | Protein Coding |
| Official Symbol | SDC3 |
| Official Name | syndecan 3 [Source:HGNC Symbol;Acc:HGNC:10660] |
| Ensembl ID | ENSG00000162512 |
| Bio databases IDs | |
| Aliases | syndecan 3, syndecan proteoglycan 3 |
| Synonyms | KIAA0468, mKIAA0468, SDCN, syn-3, SYND3, syndecan 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SDC3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- putative band 4.1 homologues' binding motif
- Syndecan domain
- cytoplasmic domain
- ectodomain
- C2 region of the Syndecan family
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the SDC3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- osteoarthritis
- rheumatoid arthritis
- early missed abortion
- obesity
- juvenile dermatomyositis
- psoriatic arthritis
- Duchenne muscular dystrophy
- autosomal dominant Emery-Dreifuss muscular dystrophy
- hyperphagia
role in cell
- expression in
- proliferation
- cell death
- phosphorylation in
- number
- quantity
- migration
- formation
- adhesion
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- raft fractions
- Golgi lumen
- perinodal process
- Cytoplasm
- cell surface
- perinuclear region
- cellular membrane
- lysosomal compartment
- nodes of Ranvier
- neurites
- gap junctions
- axons
- microspikes
- synaptosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SDC3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell migration
Cellular Component
Where in the cell the gene product is active
- microspike
- membrane
- lysosomal lumen
- Golgi lumen
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding