Sdc3 Gene Summary [Mouse]
Predicted to enable identical protein binding activity. Predicted to be involved in cell adhesion; cell migration; and regulation of cell migration. Located in microspike. Is expressed in several structures, including brain; limb; lower jaw; urinary system; and vibrissa follicle. Human ortholog(s) of this gene implicated in obesity. Orthologous to human SDC3 (syndecan 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sdc3 |
| Official Name | syndecan 3 [Source:MGI Symbol;Acc:MGI:1349163] |
| Ensembl ID | ENSMUSG00000025743 |
| Bio databases IDs | |
| Aliases | syndecan 3 |
| Synonyms | KIAA0468, mKIAA0468, SDCN, syn-3, SYND3, syndecan 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sdc3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- putative band 4.1 homologues' binding motif
- Syndecan domain
- cytoplasmic domain
- ectodomain
- C2 region of the Syndecan family
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Sdc3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- osteoarthritis
- rheumatoid arthritis
- early missed abortion
- obesity
- juvenile dermatomyositis
- psoriatic arthritis
- Duchenne muscular dystrophy
- autosomal dominant Emery-Dreifuss muscular dystrophy
- hyperphagia
role in cell
- expression in
- proliferation
- cell death
- phosphorylation in
- number
- quantity
- migration
- formation
- adhesion
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- raft fractions
- Golgi lumen
- perinodal process
- Cytoplasm
- cell surface
- perinuclear region
- cellular membrane
- lysosomal compartment
- nodes of Ranvier
- neurites
- gap junctions
- axons
- microspikes
- synaptosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sdc3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell migration
Cellular Component
Where in the cell the gene product is active
- microspike
- membrane
- lysosomal lumen
- Golgi lumen
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding