ADGRL4 Gene Summary [Human]
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in cytoplasmic vesicle and plasma membrane. Predicted to be integral component of plasma membrane. Biomarker of glioblastoma and hypertrophic cardiomyopathy. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ADGRL4 |
| Official Name | adhesion G protein-coupled receptor L4 [Source:HGNC Symbol;Acc:HGNC:20822] |
| Ensembl ID | ENSG00000162618 |
| Bio databases IDs | |
| Aliases | adhesion G protein-coupled receptor L4 |
| Synonyms | 1110033N21RIK, adhesion G protein-coupled receptor L4, ELTD1, ETL, ETL1, KPG 003 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ADGRL4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- 7 transmembrane receptor (Secretin family)
- GPCR-Autoproteolysis INducing (GAIN) domain
- EGF domain
- GPCR proteolysis site, GPS, motif
- seven-transmembrane G protein-coupled receptor superfamily
- EGF_CA
Pathways
Biological processes and signaling networks where the ADGRL4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ADGRL4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- cell surface receptor signaling pathway
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- membrane
- cytoplasmic vesicle
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- calcium ion binding