AIP Gene Summary [Human]
The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]
Details
| Type | Protein Coding |
| Official Symbol | AIP |
| Official Name | aryl hydrocarbon receptor interacting protein [Source:HGNC Symbol;Acc:HGNC:358] |
| Ensembl ID | ENSG00000110711 |
| Bio databases IDs | |
| Aliases | aryl hydrocarbon receptor interacting protein, hepatitis B virus X-associated cellular protein 2, aryl hydrocarbon receptor-associated protein 9, FKBP prolyl isomerase 16, X-associated protein-2, FK506-binding protein 37, Ah receptor activated 9 |
| Synonyms | AHR interacting HSP90 co-chaperone, ARA9, aryl-hydrocarbon receptor-interacting protein, D19Bwg1412e, FKBP16, FKBP37, PITA1, SMTPHN, XAP-2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AIP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- immunophilin homology domain
- transcription regulator
- transcription co-activator
- aryl hydrocarbon receptor binding
- peptidylprolyl isomerase
- transcription cofactor
- enzyme binding
- FKBP domain
- protein domain specific binding
- protein binding
Pathways
Biological processes and signaling networks where the AIP gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- benign neoplasia
- adenoma formation
- gigantism
- omphalocele
- head and neck neuroendocrine neoplasia
- head and neck neoplasia
- sporadic acromegaly pituitary macroadenoma
- edema
- hereditary cancer-predisposing syndrome
role in cell
- expression in
- apoptosis
- activation
- production in
- activation in
- binding in
- maintenance in
- DNMDP sensitivity
- cohesion in
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- membrane fraction
- Cytoplasm
- cellular membrane
- Plasma Membrane
- cytosol
- nucleoplasm
- plasma
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AIP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein targeting to mitochondrion
- protein maturation by protein folding
- positive regulation of transcription, DNA-dependent
- regulation of protein kinase A signaling cascade
- xenobiotic metabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- aryl hydrocarbon receptor complex
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- peptidyl-prolyl cis-trans isomerase activity
- protein binding
- GAF domain binding
- transcription coactivator activity
- aryl hydrocarbon receptor binding
- unfolded protein binding