DNAI3 Gene Summary [Human]
Enables Arp2/3 complex binding activity. Involved in negative regulation of Arp2/3 complex-mediated actin nucleation and negative regulation of cell migration. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | DNAI3 |
| Official Name | dynein axonemal intermediate chain 3 [Source:HGNC Symbol;Acc:HGNC:30711] |
| Ensembl ID | ENSG00000162643 |
| Bio databases IDs | |
| Aliases | dynein axonemal intermediate chain 3 |
| Synonyms | 4931433A13Rik, DIC3, dynein axonemal intermediate chain 3, IC140, Ida7, NYD-SP29, RGD1563105, WDR63 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DNAI3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- WD40 repeats
- WD domain, G-beta repeat
- WD40
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DNAI3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium movement involved in cell motility
- positive regulation of osteoblast differentiation
- inner dynein arm assembly
- negative regulation of Arp2/3 complex-mediated actin nucleation
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- inner dynein arm
- cytoplasm
- axonemal dynein complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- dynein heavy chain binding
- dynein light chain binding
- Arp2/3 complex binding