GALM Gene Summary [Human]

This gene encodes an enzyme that catalyzes the epimerization of hexose sugars such as glucose and galactose. The encoded protein is expressed in the cytoplasm and has a preference for galactose. The encoded protein may be required for normal galactose metabolism by maintaining the equilibrium of alpha and beta anomers of galactose.[provided by RefSeq, Mar 2009]

Details

Type
Protein Coding
Official Symbol
GALM
Official Name
galactose mutarotase [Source:HGNC Symbol;Acc:HGNC:24063]
Ensembl ID
ENSG00000143891
Bio databases IDs NCBI: 130589 Ensembl: ENSG00000143891
Aliases galactose mutarotase, aldose 1-epimerase, aldose mutarotase, galactomutarotase
Synonyms A530057M15RIK, aldose 1-epimerase, BLOCK25, GALAC4, galactose mutarotase, GLAT, HEL-S-63p, IBD1
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GALM often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • aldose 1-epimerase superfamily
  • aldose 1-epimerase
  • enzyme

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • major depression
  • galactosemia type IV
  • genu valgum
regulates
  • D-glucose
  • D-galactose
  • carbohydrate

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human GALM gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • carbohydrate metabolic process
  • galactose catabolic process via UDP-galactose
  • galactose metabolic process
  • glucose metabolic process

Cellular Component

Where in the cell the gene product is active
  • extracellular vesicular exosome
  • cytoplasm

Molecular Function

What the gene product does at the molecular level
  • protein homodimerization activity
  • aldose 1-epimerase activity
  • carbohydrate binding

Gene-Specific Assays for Results You Can Trust

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