ARL5A Gene Summary [Human]
The protein encoded by this gene belongs to the ARF family of GTP-binding proteins. With its distinctive nuclear/nucleolar localization and interaction with HP1alpha, the protein is developmentally regulated and may play a role(s) in nuclear dynamics and/or signaling cascades during embryonic development. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | ARL5A |
| Official Name | ADP ribosylation factor like GTPase 5A [Source:HGNC Symbol;Acc:HGNC:696] |
| Ensembl ID | ENSG00000162980 |
| Bio databases IDs | |
| Aliases | ADP ribosylation factor like GTPase 5A |
| Synonyms | 2410015N24Rik, 2810410P22RIK, AA408731, ADP-ribosylation factor-like 5A, ARF like GTPase 5A, ARFLP5, ARL5, T25534 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ARL5A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sar1p-like members of the Ras-family of small GTPases
- GTP binding
- ADP-ribosylation factor family
- Ras family
- 50S ribosome-binding GTPase
- enzyme
- Ras of Complex, Roc, domain of DAPkinase
- ADP-ribosylation factor
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ARL5A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle-mediated transport
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- trans-Golgi network
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- GTP binding
- GTPase activity