GOLGA4 Gene Summary [Human]
The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This protein has been postulated to play a role in Rab6-regulated membrane-tethering events in the Golgi apparatus. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]
Details
| Type | Protein Coding |
| Official Symbol | GOLGA4 |
| Official Name | golgin A4 [Source:HGNC Symbol;Acc:HGNC:4427] |
| Ensembl ID | ENSG00000144674 |
| Bio databases IDs | |
| Aliases | golgin A4, golgin 245 |
| Synonyms | AC097359.1, CRPF46, GCP2, GOLG, GOLGIN-245, golgin A4, MU-RMS-40.18, Olp-1, p230, TGN230, Trans-Golgi p230 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GOLGA4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mitotic checkpoint protein
- chromosome segregation protein SMC, primarily archaeal type
- exonuclease SbcC
- rad50
- GRIP domain
- enzyme binding
- Myosin tail
- helix-rich Mycoplasma protein
- protein binding
- Protein of unknown function (DUF3584)
- Alpha helical coiled-coil rod protein (HCR)
- chromosome segregation protein SMC, common bacterial type
- RecF/RecN/SMC N terminal domain
- golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- breast cancer
- diabetic retinopathy
- senile lentigo
regulates
- mannosidase 2
- MPR
role in cell
- apoptosis
- proliferation
- extension
- innate immune response in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear Golgi regions
- perinuclear region
- cellular membrane
- Plasma Membrane
- Golgi Apparatus
- cytosol
- Golgi membrane
- trans Golgi network
- nucleoplasm
- plasma
- trans Golgi cisternae
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GOLGA4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle-mediated transport
- Golgi to plasma membrane protein transport
- positive regulation of axon extension
- Golgi vesicle transport
Cellular Component
Where in the cell the gene product is active
- trans-Golgi network
- extracellular vesicular exosome
- cytoplasm
- cytosol
- Golgi apparatus
- Golgi membrane
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase binding
- small GTPase binding