S100A12 Gene Summary [Human]
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. The protein includes an antimicrobial peptide which has antibacterial activity. [provided by RefSeq, Nov 2014]
Details
| Type | Protein Coding |
| Official Symbol | S100A12 |
| Official Name | S100 calcium binding protein A12 [Source:HGNC Symbol;Acc:HGNC:10489] |
| Ensembl ID | ENSG00000163221 |
| Bio databases IDs | |
| Aliases | S100 calcium binding protein A12, extracellular newly identified RAGE-binding protein, calcium-binding protein in amniotic fluid 1, migration inhibitory factor-related protein 6, neutrophil S100 protein, calgranulin C |
| Synonyms | CAAF1, CAGC, calgranulin C, CGRP, ENRAGE, MRP-6, p6, RAGE binding, S100 calcium binding protein A12, S100 NEUTROPHIL |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human S100A12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- copper ion binding
- S-100/ICaBP type calcium binding domain
- zinc ion binding
- calcium ion binding
- EFh
- protein binding
- receptor binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- thoracic aortic aneurysm
- psoriasis
- rheumatoid arthritis
- ulcerative colitis
- septic shock
- Crohn disease
- polyarticular juvenile rheumatoid arthritis
- ischemic stroke
- renal cell cancer
role in cell
- activation in
- production in
- expression in
- activation
- invasion by
- angiogenesis by
- activity
- oxidative stress response
- chemotaxis
- inflammation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- secretory granule lumen
- cytoskeleton
- Extracellular Space
- Nucleus
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human S100A12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of MAP kinase activity
- positive regulation of inflammatory response
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- endothelial cell migration
- mast cell activation
- positive regulation of NF-kappaB transcription factor activity
- defense response to bacterium
- inflammatory response
- monocyte chemotaxis
- innate immune response
- xenobiotic metabolic process
- killing of cells of other organism
- neutrophil chemotaxis
- defense response to fungus
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoskeleton
- cytoplasm
- cytosol
- secretory granule lumen
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- identical protein binding
- protein binding
- copper ion binding
- calcium ion binding
- calcium-dependent protein binding
- RAGE receptor binding