CRP Gene Summary [Human]
The protein encoded by this gene belongs to the pentraxin family which also includes serum amyloid P component protein and pentraxin 3. Pentraxins are involved in complement activation and amplification via communication with complement initiation pattern recognition molecules, but also complement regulation via recruitment of complement regulators. The encoded protein has a calcium dependent ligand binding domain with a distinctive flattened beta-jellyroll structure. It exists in two forms as either a pentamer in circulation or as a nonsoluble monomer in tissues. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. Elevated expression of the encoded protein is associated with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. [provided by RefSeq, Aug 2020]
Details
| Type | Protein Coding |
| Official Symbol | CRP |
| Official Name | C-reactive protein [Source:HGNC Symbol;Acc:HGNC:2367] |
| Ensembl ID | ENSG00000132693 |
| Bio databases IDs | |
| Aliases | C-reactive protein, pentraxin 1 |
| Synonyms | Aa1249, Ab1-341, Ab2-196, Ac1-114, Ac1262, Ac2-069, Ba2-693, C REACTIVE, C-reactive protein, C-reactive protein, pentraxin-related, PTX1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CRP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Concanavalin A-like lectin/glucanases superfamily
- cholesterol binding
- binding protein
- LamG
- signal peptide
- calcium ion binding
- protein binding
- low-density lipoprotein receptor binding
- low-density lipoprotein binding
- calcium binding loop
- identical protein binding
Pathways
Biological processes and signaling networks where the CRP gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- obesity
- atrial fibrillation
- cardiovascular disorder
- hypertension
- chronic kidney disease
- ischemic cardiomyopathy
- chronic stable angina
- non-insulin-dependent diabetes mellitus
- anemia
role in cell
- phosphorylation in
- expression in
- apoptosis
- quantity
- migration
- production in
- binding
- binding in
- activation
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- Nucleus
- cytosol
- growth cone
- filopodia
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CRP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vasoconstriction
- opsonization
- acute-phase response
- inflammatory response
- negative regulation of mononuclear cell proliferation
- innate immune response
- positive regulation of gene expression
- negative regulation of macrophage derived foam cell differentiation
- negative regulation of lipid storage
- defense response to Gram-positive bacterium
- regulation of interleukin-8 production
- positive regulation of superoxide anion generation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- virion binding
- identical protein binding
- protein binding
- low-density lipoprotein particle receptor binding
- choline binding
- calcium ion binding
- complement component C1q binding
- low-density lipoprotein particle binding