NPPC
NPPC Gene Summary
This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cardiac natriuretic peptides CNP-53, CNP-29 and CNP-22, which belong to the natriuretic family of peptides. The encoded peptides exhibit vasorelaxation activity in laboratory animals and elevated levels of CNP-22 have been observed in the plasma of chronic heart failure patients. [provided by RefSeq, Oct 2015]
Details
| Type | Protein Coding |
| Official Symbol | NPPC |
| Official Name | natriuretic peptide C [Source:HGNC Symbol;Acc:HGNC:7941] |
| Ensembl ID | ENSG00000163273 |
| Bio databases IDs | |
| Aliases | natriuretic peptide C |
| Synonyms | CNP,CNP2,lbab,natriuretic peptide C,natriuretic peptide type C |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Atrial natriuretic peptide
- hormone
- receptor binding
- neuropeptide hormone
Pathways
Biological processes and signaling networks where the NPPC gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- NPR2
- FZR1
- STK16
- EYA2
- NPR3
- PTPN1
- NPR1
- MTMR12
- EYA3
- MTMR14
disease
- disproportionate dwarfism
- weight gain
- growth failure
- aortic stenosis
regulated by
- lipopolysaccharide
- acetylcholine
- 18-alpha-glycyrrhetinic acid
- FURIN
- FSH
- dexamethasone
- AGT
- SMAD4
- dec-RVKR-CMK
- NPPA
regulates
- oxygen
- UCP1
- dopamine
- norepinephrine
- Ca2+
- PPARG
- NPR2
- NPPA
- cyclic GMP
- GUCY1B1
role in cell
- expression in
- proliferation
- differentiation
- production in
- apoptosis
- accumulation in
- migration
- hypertrophy
- contractility
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- Plasma Membrane
- pedicels
- secretory granules
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the NPPC gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- cGMP-mediated signaling
- cGMP biosynthetic process
- regulation of multicellular organism growth
- negative regulation of oocyte maturation
- negative regulation of cell proliferation
- post-embryonic development
- gastric emptying
- response to axon injury
- response to xenobiotic stimulus
- positive regulation of osteoblast differentiation
- negative regulation of neuron apoptotic process
- response to ethanol
- regulation of smooth muscle cell proliferation
- negative regulation of collagen biosynthetic process
- response to ischemia
- response to hypoxia
- ossification
- angiogenesis
- cumulus cell differentiation
- positive regulation of cGMP-mediated signaling
- negative regulation of DNA biosynthetic process
- negative regulation of meiotic cell cycle
- receptor guanylyl cyclase signaling pathway
- protein folding
- cellular calcium ion homeostasis
- blood vessel remodeling
- chromosome organization
- growth plate cartilage chondrocyte differentiation
- growth plate cartilage chondrocyte proliferation
- multicellular organismal locomotion
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
- secretory granule
- macromolecular complex
- extracellular region
MOLECULAR FUNCTION
What the gene product does at the molecular level
- hormone receptor binding
- hormone activity
- receptor binding