CLEC3B Gene Summary [Human]
Enables calcium ion binding activity; heparin binding activity; and kringle domain binding activity. Involved in bone mineralization and cellular response to transforming growth factor beta stimulus. Located in cytoplasm; extracellular space; and granular component. Part of collagen-containing extracellular matrix. Implicated in osteoarthritis. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | CLEC3B |
| Official Name | C-type lectin domain family 3 member B [Source:HGNC Symbol;Acc:HGNC:11891] |
| Ensembl ID | ENSG00000163815 |
| Bio databases IDs | |
| Aliases | C-type lectin domain family 3 member B |
| Synonyms | C-type lectin domain family 3 member B, C-type lectin domain family 3, member B, LOC100912012, MCDR4, TETRANECTIN, TN, TNA |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CLEC3B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- Lectin C-type domain
- calcium ion binding
- protein domain specific binding
- protein binding
- carbohydrate binding
- heparin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- serous ovarian adenocarcinoma
- serous ovarian cancer
- COVID-19
- retinal macular dystrophy type 4
- colorectal cancer
- diabetic nephropathy
- Alzheimer disease
- placenta accreta spectrum
- primary colorectal cancer
- Hutchinson-Gilford progeria syndrome
regulates
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- secretory granule lumen
- Cytoplasm
- granular components
- extracellular matrix
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CLEC3B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to transforming growth factor beta stimulus
- bone mineralization
- ossification
- positive regulation of plasminogen activation
Cellular Component
Where in the cell the gene product is active
- granular component
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- platelet dense granule lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- calcium ion binding
- kringle domain binding
- heparin binding
- carbohydrate binding