NFIX Gene Summary [Human]
The protein encoded by this gene is a transcription factor that binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3 in viral and cellular promoters. The encoded protein can also stimulate adenovirus replication in vitro. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012]
Details
| Type | Protein Coding |
| Official Symbol | NFIX |
| Official Name | nuclear factor I X [Source:HGNC Symbol;Acc:HGNC:7788] |
| Ensembl ID | ENSG00000008441 |
| Bio databases IDs | |
| Aliases | nuclear factor I X, CCAAT-binding transcription factor |
| Synonyms | CTF, MALNS, MRSHSS, NF1A, NF1-X, NF1/X, Nf1x1, NF-I/X, Nuclear factor 1/X, nuclear factor I X, nuclear factor I/X, SOTOS2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NFIX often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- DNA binding domain
- nucleic acid binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
- N-terminal Mad Homology 1 (MH1) domain
- Nuclear factor I protein pre-N-terminus
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- MH1 domain
- CTF/NF-I family transcription modulation region
- transcription factor activity
Pathways
Biological processes and signaling networks where the NFIX gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight loss
- Alzheimer disease
- Sotos syndrome 2
- Marshall-Smith syndrome
- non-insulin-dependent diabetes mellitus
- schizophrenia
- marfanoid habitus with mental retardation
- hereditary disorder
- scoliosis
- weight gain
role in cell
- apoptosis
- cell death
- growth
- expression in
- proliferation
- accumulation in
- recruitment in
- migration
- formation
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nuclear fraction
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NFIX gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- DNA replication
- transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity