DNAJB14 Gene Summary [Human]
Enables Hsp70 protein binding activity. Involved in cellular protein-containing complex assembly and chaperone cofactor-dependent protein refolding. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | DNAJB14 |
| Official Name | DnaJ heat shock protein family (Hsp40) member B14 [Source:HGNC Symbol;Acc:HGNC:25881] |
| Ensembl ID | ENSG00000164031 |
| Bio databases IDs | |
| Aliases | DnaJ heat shock protein family (Hsp40) member B14 |
| Synonyms | 5730496F10Rik, DnaJ heat shock protein family (Hsp40) member B14, EGNR9427, PRO34683 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DNAJB14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DnaJ domain
- DnaJ
- Hsp70 protein binding
- DnaJ molecular chaperone homology domain
- enzyme
- protein binding
- Domain of unknown function (DUF1977)
Pathways
Biological processes and signaling networks where the DNAJB14 gene in human plays a role, providing insight into its function and relevance in health or disease.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DNAJB14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- macromolecular complex assembly
- chaperone mediated protein folding requiring cofactor
- cellular response to misfolded protein
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nuclear membrane
- membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- Hsp70 protein binding