LMBR1L Gene Summary [Human]
Enables transmembrane signaling receptor activity. Involved in receptor-mediated endocytosis and signal transduction. Located in endoplasmic reticulum membrane and plasma membrane. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | LMBR1L |
| Official Name | limb development membrane protein 1 like [Source:HGNC Symbol;Acc:HGNC:18268] |
| Ensembl ID | ENSG00000139636 |
| Bio databases IDs | |
| Aliases | limb development membrane protein 1 like |
| Synonyms | 1110013E13Rik, D15Ertd735e, limb development membrane protein 1-like, limb region 1 like, LIMR, RGD1309631 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LMBR1L often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- LMBR1-like membrane protein
- protein binding
- transmembrane receptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- granules
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LMBR1L gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- T cell differentiation
- signal transduction
- T cell proliferation
- T cell apoptotic process
- hemopoietic stem cell differentiation
- Wnt receptor signaling pathway
- receptor-mediated endocytosis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- transmembrane signaling receptor activity