ISCA2 Gene Summary [Human]
The protein encoded by this gene is an A-type iron-sulfur cluster (ISC) protein found in mitochondria. The encoded protein appears to be involved in the maturation of mitochondrial iron-sulfur proteins. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Details
| Type | Protein Coding |
| Official Symbol | ISCA2 |
| Official Name | iron-sulfur cluster assembly 2 [Source:HGNC Symbol;Acc:HGNC:19857] |
| Ensembl ID | ENSG00000165898 |
| Bio databases IDs | |
| Aliases | iron-sulfur cluster assembly 2 |
| Synonyms | 0710001C05Rik, 5730594E03Rik, c14 5557, HBLD1, iron-sulfur cluster assembly 2, iron-sulphur cluster assembly 2, ISA2, MMDS4, RGD1563216 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ISCA2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Iron-sulphur cluster biosynthesis
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- multiple mitochondrial dysfunctions syndrome type 4
- hereditary disorder
- multiple mitochondrial dysfunctions syndrome
- mitochondrial disorder
role in cell
- enlargement
- enlargement in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ISCA2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- iron-sulfur cluster assembly
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- iron ion binding
- 4 iron, 4 sulfur cluster binding
- 2 iron, 2 sulfur cluster binding