Isca2 Gene Summary [Rat]
Predicted to enable identical protein binding activity; iron ion binding activity; and iron-sulfur cluster binding activity. Predicted to be involved in iron-sulfur cluster assembly and protein maturation. Predicted to be part of mitochondrial [4Fe-4S] assembly complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 4. Orthologous to human ISCA2 (iron-sulfur cluster assembly 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Isca2 |
| Official Name | iron-sulfur cluster assembly 2 [Source:RGD Symbol;Acc:1563216] |
| Ensembl ID | ENSRNOG00000012085 |
| Bio databases IDs | |
| Aliases | iron-sulfur cluster assembly 2 |
| Synonyms | 0710001C05Rik, 5730594E03Rik, c14 5557, HBLD1, iron-sulfur cluster assembly 2, iron-sulphur cluster assembly 2, ISA2, MMDS4, RGD1563216 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Isca2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Iron-sulphur cluster biosynthesis
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- multiple mitochondrial dysfunctions syndrome type 4
- hereditary disorder
- multiple mitochondrial dysfunctions syndrome
- mitochondrial disorder
regulates
- aconitase
- LIAS
- Mitochondrial ETC 1
- SDH
role in cell
- enlargement
- enlargement in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Isca2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- iron-sulfur cluster assembly
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- iron ion binding
- 4 iron, 4 sulfur cluster binding
- 2 iron, 2 sulfur cluster binding