KCNC2 Gene Summary [Human]

The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Details

Type
Protein Coding
Official Symbol
KCNC2
Official Name
potassium voltage-gated channel subfamily C member 2 [Source:HGNC Symbol;Acc:HGNC:6234]
Ensembl ID
ENSG00000166006
Bio databases IDs NCBI: 3747 Ensembl: ENSG00000166006
Aliases potassium voltage-gated channel subfamily C member 2
Synonyms AW047325, B230117I07, DEE103, KShIIIA, KV3.2, potassium voltage gated channel, Shaw-related subfamily, member 2, potassium voltage-gated channel subfamily C member 2
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KCNC2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • delayed rectifier potassium channel
  • voltage-gated potassium channel
  • Ion transport protein
  • Broad-Complex, Tramtrack and Bric a brac
  • BTB_POZ
  • transmembrane domain
  • ion channel binding
  • protein binding
  • pore domain
  • voltage-gated ion channel
  • ion channel

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
  • epileptic seizure
  • developmental and epileptic encephalopathy type 103
  • nerve injury
  • nonarteritic ischemic optic neuropathy
  • multiple sclerosis
  • idiopathic scoliosis
  • seizures
  • relapsing-remitting multiple sclerosis
  • tonic-clonic seizure
  • myoclonus
regulated by
regulates
role in cell
  • afterhyperpolarization
  • response by
  • hyperpolarization
  • action potential

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • intracellular membrane-bounded organelle
  • cellular membrane
  • vesicles
  • apical membrane
  • presynaptic membrane
  • postsynaptic membrane
  • basolateral membrane
  • axonal membrane
  • synapse
  • perikaryon
  • axons
  • dendrites
  • axon terminals

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human KCNC2 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • potassium ion transmembrane transport
  • response to amine stimulus
  • globus pallidus development
  • protein homooligomerization
  • protein heterooligomerization
  • response to light intensity
  • response to organic cyclic compound
  • nitric oxide-cGMP-mediated signaling pathway
  • optic nerve development
  • potassium ion transport
  • response to ethanol
  • cellular response to ammonium ion
  • cellular response to toxin
  • cellular response to nitric oxide
  • response to magnesium ion
  • membrane hyperpolarization
  • regulation of action potential

Cellular Component

Where in the cell the gene product is active
  • presynaptic membrane
  • dendrite membrane
  • voltage-gated potassium channel complex
  • neuronal cell body membrane
  • synapse
  • perikaryon
  • plasma membrane
  • axon terminus
  • dendrite
  • postsynaptic membrane
  • terminal button
  • cell body
  • membrane
  • vesicle
  • axolemma
  • basolateral plasma membrane
  • apical plasma membrane
  • axon

Molecular Function

What the gene product does at the molecular level
  • voltage-gated potassium channel activity
  • delayed rectifier potassium channel activity
  • ion channel binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.