HRH2 Gene Summary [Human]
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Details
| Type | Protein Coding |
| Official Symbol | HRH2 |
| Official Name | histamine receptor H2 [Source:HGNC Symbol;Acc:HGNC:5183] |
| Ensembl ID | ENSG00000113749 |
| Bio databases IDs | |
| Aliases | histamine receptor H2 |
| Synonyms | H2, H2R, H2 receptor, H2 receptors, HH2R, histamine H2 receptor, HISTAMINE receptor H2, HR2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HRH2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- histamine receptor
- Cholecystokinin A receptor, N-terminal
- binding protein
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the HRH2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- histamine
- iodoaminopotentidine
- cimetidine
- buclizine
- famotidine
- nizatidine
- methantheline
- epinastine
- ranitidine
- doxepin
disease
- infection
- cancer
- mania
- alcoholism
- bipolar disorder
- hyperplasia
- mycosis fungoides
- Sézary syndrome
- gastroesophageal reflux
- aspiration pneumonia
role in cell
- migration
- growth
- proliferation
- production in
- phosphorylation in
- apoptosis
- expression in
- quantity
- signaling in
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HRH2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- gastric acid secretion
- immune response
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- positive regulation of vasoconstriction
- synaptic transmission
Cellular Component
Where in the cell the gene product is active
- dendrite
- synapse
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- histamine receptor activity
- neurotransmitter receptor activity
- serotonin receptor activity