SSTR3 Gene Summary [Human]
This gene encodes a member of the somatostatin receptor protein family. Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This protein is functionally coupled to adenylyl cyclase. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Details
| Type | Protein Coding |
| Official Symbol | SSTR3 |
| Official Name | somatostatin receptor 3 [Source:HGNC Symbol;Acc:HGNC:11332] |
| Ensembl ID | ENSG00000278195 |
| Bio databases IDs | |
| Aliases | somatostatin receptor 3 |
| Synonyms | Smstr28, Smstr-3, somatostatin receptor 3, SS-3-R, SSR-28, SST3, Sst3r, SSTR |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SSTR3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- somatostatin receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- receptor binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the SSTR3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- acromegaly
- Cushing syndrome
- colorectal cancer
- Prader-Willi syndrome
- neuroendocrine gastroenteropancreatic tumor
- metastatic malignant gastrointestinal neuroendocrine tumor
- therapy-associated diarrhea
- neuroendocrine neoplasm
- pheochromocytoma
role in cell
- binding in
- apoptosis
- production in
- mobilization in
- branching in
- degradation in
- dissociation in
- branching
- outgrowth in
- outgrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- non-motile cilium
- cilia
- cell surface
- cellular membrane
- neurites
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SSTR3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- induction of apoptosis by hormones
- cellular response to estradiol stimulus
- neuropeptide signaling pathway
- forebrain development
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- cerebellum development
- negative regulation of cell proliferation
- cellular response to glucocorticoid stimulus
- spermatogenesis
- cell-cell signaling
- response to starvation
Cellular Component
Where in the cell the gene product is active
- cilium
- cilium membrane
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- neuropeptide binding
- protein binding
- receptor binding
- somatostatin receptor activity