CMTM5 Gene Summary [Human]

This gene encodes a member of the chemokine-like factor superfamily. This family of genes encodes multi-pass membrane proteins that are similar to both the chemokine and the transmembrane 4 superfamilies of signaling molecules. The encoded protein may exhibit tumor suppressor activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Details

Type
Protein Coding
Official Symbol
CMTM5
Official Name
CKLF like MARVEL transmembrane domain containing 5 [Source:HGNC Symbol;Acc:HGNC:19176]
Ensembl ID
ENSG00000166091
Bio databases IDs NCBI: 116173 Ensembl: ENSG00000166091
Aliases CKLF like MARVEL transmembrane domain containing 5
Synonyms 1500005P16Rik, 2900052H21Rik, CKLF-like MARVEL transmembrane domain containing 5, CKLFSF5
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CMTM5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Membrane-associating domain
  • protein binding
  • cytokine

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • Alzheimer disease
  • multiple sclerosis
regulated by
role in cell
  • proliferation
  • differentiation
  • migration
  • abnormal morphology
  • invasion

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • cellular membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human CMTM5 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • chemotaxis
  • negative regulation of myoblast differentiation
  • signal transduction

Cellular Component

Where in the cell the gene product is active
  • extracellular space
  • membrane

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • cytokine activity

Gene-Specific Assays for Results You Can Trust

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