TMPRSS5 Gene Summary [Human]
This gene encodes a protein that belongs to the serine protease family. Serine proteases are known to be involved in many physiological and pathological processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Details
| Type | Protein Coding |
| Official Symbol | TMPRSS5 |
| Official Name | transmembrane serine protease 5 [Source:HGNC Symbol;Acc:HGNC:14908] |
| Ensembl ID | ENSG00000166682 |
| Bio databases IDs | |
| Aliases | transmembrane serine protease 5, spinesin |
| Synonyms | AMP, SPINESIN, transmembrane protease, serine 5 (spinesin), transmembrane serine protease 5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TMPRSS5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Scavenger receptor cysteine-rich domain
- protease domain
- Trypsin-like serine protease
- trypsin
- Tryp_SPc
- serine endopeptidase
- peptidase
- Trypsin-like peptidase domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TMPRSS5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
Cellular Component
Where in the cell the gene product is active
- neuronal cell body
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase activity
- peptidase activity