TUBB6 Gene Summary [Human]
Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Located in microtubule. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TUBB6 |
| Official Name | tubulin beta 6 class V [Source:HGNC Symbol;Acc:HGNC:20776] |
| Ensembl ID | ENSG00000176014 |
| Bio databases IDs | |
| Aliases | tubulin beta 6 class V, tubulin beta MGC4083, class V beta-tubulin |
| Synonyms | 2310057H16Rik, BB220206, FPVEPD, HsT1601, MGC4083, RGD1305887, TUBB-5, Tubulin Beta 5, tubulin beta 6 class V, tubulin, beta 6 class V, Tubulin β 5, tubulin β 6 class V, tubulin, β 6 class V |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TUBB6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tubulin protein family of FtsZ and CetZ-like
- Tubulin C-terminal domain
- Tubulin/FtsZ family, GTPase domain
- protein binding
- Tubulin/FtsZ family, C-terminal domain
Pathways
Biological processes and signaling networks where the TUBB6 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- ptosis
- congenital facial palsy with ptosis and velopharyngeal dysfunction
- optic atrophy
role in cell
- pyroptosis
- disruption
- disruption in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- Nucleus
- microtubules
- cytoplasmic bridges
- cytosol
- synaptosomes
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TUBB6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- microtubule cytoskeleton organization
- mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- intercellular bridge
- microtubule cytoskeleton
- extracellular vesicular exosome
- mitotic spindle
- cytoplasm
- microtubule
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- metal ion binding
- GTPase activity
- structural constituent of cytoskeleton