Htr3a Gene Summary [Rat]
Enables serotonin-gated monoatomic cation channel activity. Involved in several processes, including behavioral response to ethanol; positive regulation of ion transmembrane transporter activity; and response to cocaine. Located in axon and neuronal cell body. Is active in glutamatergic synapse; postsynaptic membrane; and presynaptic membrane. Biomarker of alcohol dependence. Human ortholog(s) of this gene implicated in alcohol dependence; cocaine dependence; heroin dependence; irritable bowel syndrome; and nicotine dependence. Orthologous to human HTR3A (5-hydroxytryptamine receptor 3A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Htr3a |
| Official Name | 5-hydroxytryptamine receptor 3A [Source:RGD Symbol;Acc:61818] |
| Ensembl ID | ENSRNOG00000006595 |
| Bio databases IDs | |
| Aliases | 5-hydroxytryptamine receptor 3A |
| Synonyms | 5-HT-3, 5-HT3A, 5-HT3R, 5-hydroxytryptamine receptor 3A, 5-hydroxytryptamine (serotonin) receptor 3A, HTR3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Htr3a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- intracellular loop
- transmembrane domain of Cys-loop neurotransmitter-gated ion channels
- channel/pore class transporter
- serotonin binding
- extracellular ligand-gated ion channel
- Cation transporter family protein
- protein binding
- identical protein binding
- ion channel
- LGIC_ECD
- neurotransmitter receptor
- Neurotransmitter-gated ion-channel transmembrane region
- ligand-binding domain
- Neurotransmitter-gated ion-channel ligand binding domain
- transmembrane domain
- ligand-gated ion channel
- intracellular domain
- loop domain
- transmembrane receptor
- cation channel
Pathways
Biological processes and signaling networks where the Htr3a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- infection
- plasma cell myeloma
- bacterial disease
- sepsis
- Sézary syndrome
- diarrhea
- obesity
- mycosis fungoides
- viral disease
role in cell
- activation
- loss
- proliferation
- function
- complexity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- glutaminergic synapse
- Cytoplasm
- cell surface
- cellular membrane
- presynaptic membrane
- postsynaptic membrane
- cleavage furrow
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Htr3a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of excitatory postsynaptic membrane potential
- regulation of membrane potential
- ion transmembrane transport
- synaptic transmission
- serotonin receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- postsynaptic membrane
- cleavage furrow
- synapse
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- serotonin binding
- identical protein binding
- protein binding
- excitatory extracellular ligand-gated ion channel activity
- serotonin-gated cation channel activity