TPST2 Gene Summary [Human]
The protein encoded by this gene catalyzes the O-sulfation of tyrosine residues within acidic regions of proteins. The encoded protein is a type II integral membrane protein found in the Golgi body. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2018]
Details
| Type | Protein Coding |
| Official Symbol | TPST2 |
| Official Name | tyrosylprotein sulfotransferase 2 [Source:HGNC Symbol;Acc:HGNC:12021] |
| Ensembl ID | ENSG00000128294 |
| Bio databases IDs | |
| Aliases | tyrosylprotein sulfotransferase 2, transport and golgi organization 13 homolog B (Drosophila), protein-tyrosine sulfotransferase 2 |
| Synonyms | D5Ucla3, grm, grt, protein-tyrosine sulfotransferase 2, protein-tyrosine sulphotransferase 2, TANGO13B, tyrosylprotein sulfotransferase 2, Tyrosylprotein sulphotransferase 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TPST2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein homodimerization
- enzyme
- protein-tyrosine sulfotransferase
- Sulfotransferase family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- migraines
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- Burkitt lymphoma
role in cell
- expression in
- number
- motility
- morphology
- fusion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi lumen
- Endoplasmic Reticulum
- Golgi membrane
- trans Golgi network
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TPST2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- 3'-phosphoadenosine 5'-phosphosulfate metabolic process
- peptidyl-tyrosine sulfation
Cellular Component
Where in the cell the gene product is active
- Golgi membrane
- endoplasmic reticulum
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein-tyrosine sulfotransferase activity