PIP4K2C
PIP4K2C Gene Summary
Enables 1-phosphatidylinositol-4-phosphate 5-kinase activity and identical protein binding activity. Involved in several processes, including 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity; and positive regulation of autophagosome assembly. Located in several cellular components, including autophagosome; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PIP4K2C |
| Official Name | phosphatidylinositol-5-phosphate 4-kinase type 2 gamma [Source:HGNC Symbol;Acc:HGNC:23786] |
| Ensembl ID | ENSG00000166908 |
| Bio databases IDs | |
| Aliases | phosphatidylinositol-5-phosphate 4-kinase type 2 gamma |
| Synonyms | phosphatidylinositol-5-phosphate 4-kinase type 2 gamma,phosphatidylinositol-5-phosphate 4-kinase type 2 γ,phosphatidylinositol-5-phosphate 4-kinase, type II, gamma,phosphatidylinositol-5-phosphate 4-kinase, type II, γ,PI5P4K gamma,PI5P4K γ,PIP5K2C,PIPKII Gamma,PIPKII γ |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family
- 1-phosphatidylinositol-5-phosphate 4-kinase
- Phosphatidylinositol-4-phosphate 5-Kinase
- protein binding
- identical protein binding
- 1-phosphatidylinositol-4-phosphate 5-kinase
Pathways
Biological processes and signaling networks where the PIP4K2C gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- TULP3
- ARL6IP4
- LRPAP1
- TNFRSF1A
- GSPT2
- DNAAF8
- RPS21
- CDK1
- TP53
- UBE2H
disease
regulated by
- CLOCK
- WDR73
- cisplatin
- SM1-71
- chloroquine
- IgG1
- IgM
- FOLR1
- valproic acid
- Hel
regulates
- IL2
- IL12 (complex)
- IFNG
- IL12B
- p70 S6k
- 1-phosphatidyl-D-myo-inositol 4,5-bisphosphate
role in cell
- proliferation
- assembly
- quantity
- cellular infiltration by
- autophagy by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- organelle
- cell cortex
- Plasma Membrane
- Endoplasmic Reticulum
- cytosol
- nucleoplasm
- autophagic vacuoles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the PIP4K2C gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- regulation of autophagy
- phosphatidylinositol phosphorylation
- positive regulation of autophagic vacuole assembly
- negative regulation of insulin receptor signaling pathway
CELLULAR COMPONENT
Where in the cell the gene product is active
- intracellular organelle
- extracellular vesicular exosome
- cytosol
- endoplasmic reticulum
- autophagic vacuole
- plasma membrane
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein binding
- 1-phosphatidylinositol-4-phosphate 5-kinase activity
- 1-phosphatidylinositol-5-phosphate 4-kinase activity