Pip4k2c Gene Summary [Rat]
Enables 1-phosphatidylinositol-4-phosphate 5-kinase activity. Predicted to be involved in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; negative regulation of insulin receptor signaling pathway; and positive regulation of autophagosome assembly. Predicted to be located in autophagosome; cytosol; and nucleoplasm. Predicted to be active in plasma membrane. Orthologous to human PIP4K2C (phosphatidylinositol-5-phosphate 4-kinase type 2 gamma). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pip4k2c |
| Official Name | phosphatidylinositol-5-phosphate 4-kinase type 2 gamma [Source:RGD Symbol;Acc:621711] |
| Ensembl ID | ENSRNOG00000005138 |
| Bio databases IDs | |
| Aliases | phosphatidylinositol-5-phosphate 4-kinase type 2 gamma |
| Synonyms | phosphatidylinositol-5-phosphate 4-kinase type 2 gamma, phosphatidylinositol-5-phosphate 4-kinase type 2 γ, phosphatidylinositol-5-phosphate 4-kinase, type II, gamma, phosphatidylinositol-5-phosphate 4-kinase, type II, γ, PI5P4K gamma, PI5P4K γ, PIP5K2C, PIPKII Gamma, PIPKII γ |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pip4k2c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family
- 1-phosphatidylinositol-5-phosphate 4-kinase
- Phosphatidylinositol-4-phosphate 5-Kinase
- protein binding
- identical protein binding
- 1-phosphatidylinositol-4-phosphate 5-kinase
Pathways
Biological processes and signaling networks where the Pip4k2c gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- proliferation
- assembly
- quantity
- cellular infiltration by
- autophagy by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- organelle
- cell cortex
- Plasma Membrane
- Endoplasmic Reticulum
- cytosol
- nucleoplasm
- autophagic vacuoles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pip4k2c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of autophagy
- phosphatidylinositol phosphorylation
- positive regulation of autophagic vacuole assembly
- negative regulation of insulin receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- intracellular organelle
- extracellular vesicular exosome
- cytosol
- endoplasmic reticulum
- autophagic vacuole
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein binding
- 1-phosphatidylinositol-4-phosphate 5-kinase activity
- 1-phosphatidylinositol-5-phosphate 4-kinase activity