TMIGD2 Gene Summary [Human]
Enables coreceptor activity. Involved in positive regulation of T cell activation; positive regulation of angiogenesis; and positive regulation of cytokine production. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TMIGD2 |
| Official Name | transmembrane and immunoglobulin domain containing 2 [Source:HGNC Symbol;Acc:HGNC:28324] |
| Ensembl ID | ENSG00000167664 |
| Bio databases IDs | |
| Aliases | transmembrane and immunoglobulin domain containing 2, CD28 homologue, immunoglobulin-containing and proline-rich receptor-1 |
| Synonyms | CD28H, IGPR-1, transmembrane and immunoglobulin domain containing 2 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TMIGD2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- immunoglobulin domain
- Immunoglobulin like
- protein binding
- proline rich domain
- coreceptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TMIGD2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- T cell costimulation
- positive regulation of activated T cell proliferation
- positive regulation of cytokine production
- positive regulation of angiogenesis
- B cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- B cell receptor complex
Molecular Function
What the gene product does at the molecular level
- coreceptor activity
- protein binding