BECN1 Gene Summary [Human]
This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Details
| Type | Protein Coding |
| Official Symbol | BECN1 |
| Official Name | beclin 1 [Source:HGNC Symbol;Acc:HGNC:1034] |
| Ensembl ID | ENSG00000126581 |
| Bio databases IDs | |
| Aliases | beclin 1, ATG6 autophagy related 6 homolog (S. cerevisiae) |
| Synonyms | ATG6, Beclin 1, beclin 1, autophagy related, VPS30 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BECN1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- protein kinase binding
- nuclear export signal
- protein binding activity, bridging
- enzyme binding
- coiled-coil domain
- protein binding
- Apg6 BARA domain
- identical protein binding
- conserved domain
- phosphoinositide 3-kinase binding
- Apg6 coiled-coil region
- Bcl-2 homology 3 domain
- Beclin-1 BH3 domain, Bcl-2-interacting
Pathways
Biological processes and signaling networks where the BECN1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- heart disease
- epithelial neoplasia
- benign neoplasia
- epithelial cancer
- cancer
- adenoma formation
- neoplasia
- non-Hodgkin disease
- lymphomagenesis
role in cell
- cell death
- accumulation
- apoptosis
- proliferation
- expression in
- accumulation in
- ferroptosis
- cell viability
- phosphorylation in
- disruption
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- autophagosome precursor
- cytoskeleton
- perinuclear region
- cellular membrane
- Nucleus
- endosomes
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- Golgi membrane
- trans Golgi network
- mitochondrial outer membrane
- nuclear bodies
- autophagic vacuoles
- cytoplasmic vesicles
- perikaryon
- dendrites
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BECN1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- suppression by virus of host autophagy
- cellular response to amino acid starvation
- late endosome to vacuole transport
- phosphatidylinositol-3-phosphate biosynthetic process
- JNK cascade
- negative regulation of programmed cell death
- cytoplasmic pattern recognition receptor signaling pathway
- receptor catabolic process
- response to hypoxia
- autophagy
- apoptotic process
- defense response to virus
- positive regulation of cardiac muscle hypertrophy
- beta-amyloid metabolic process
- positive regulation of intrinsic apoptotic signaling pathway
- p38MAPK cascade
- macromolecular complex assembly
- SMAD protein signal transduction
- macromitophagy
- cellular response to glucose starvation
- cellular defense response
- positive regulation of autophagy
- early endosome to late endosome transport
- regulation of autophagy
- cellular response to epidermal growth factor stimulus
- regulation of macroautophagy
- positive regulation of protein kinase B signaling cascade
- negative regulation of cell proliferation
- response to iron(II) ion
- response to xenobiotic stimulus
- cellular response to copper ion
- protein targeting to lysosome
- cell division
- autophagic vacuole assembly
- cellular response to aluminum ion
- regulation of cytokinesis
- cellular response to hydrogen peroxide
- macroautophagy
- negative regulation of reactive oxygen species metabolic process
- lysosome organization
- response to vitamin E
- engulfment of apoptotic cell
- neuron development
- cellular response to nitrogen starvation
- negative regulation of apoptotic process
- positive regulation of autophagic vacuole assembly
- response to lead ion
- mitotic metaphase plate congression
Cellular Component
Where in the cell the gene product is active
- phosphatidylinositol 3-kinase complex II
- phosphatidylinositol 3-kinase complex I
- nuclear body
- external side of mitochondrial outer membrane
- pre-autophagosomal structure
- phosphatidylinositol 3-kinase complex, class III
- phagocytic vesicle
- endoplasmic reticulum
- autophagic vacuole
- endoplasmic reticulum membrane
- dendrite
- trans-Golgi network
- endosome
- cytoplasm
- mitochondrion
- cytosol
- endosome membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol 3-kinase binding
- protein kinase binding
- identical protein binding
- protein binding
- ubiquitin protein ligase binding
- GTPase binding
- protein binding, bridging
- binding, bridging