BAG3 Gene Summary [Human]
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | BAG3 |
| Official Name | BAG cochaperone 3 [Source:HGNC Symbol;Acc:HGNC:939] |
| Ensembl ID | ENSG00000151929 |
| Bio databases IDs | |
| Aliases | BAG cochaperone 3, BAG family molecular chaperone regulator 3 |
| Synonyms | BAG cochaperone 3, BCL2-associated athanogene 3, BIS, CAIR-1, MFM6, mg638 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BAG3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- IxI/V motif
- adenyl-nucleotide exchange factor
- Domain with 2 conserved Trp (W) residues
- BAG domains, present in regulator of Hsp70 proteins
- binding protein
- WW
- BAG domain
- protein binding
- chaperone binding
- PXXP motif
- WW domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- heart failure
- systolic heart failure
- hepatic steatosis
- cardiomyopathy
- epileptic seizure
- autosomal dominant distal hereditary motor neuropathy
- chronic obstructive pulmonary disease
- BAG3-related myofibrillar myopathy
- breast cancer
role in cell
- phosphorylation in
- expression in
- ubiquitination in
- apoptosis
- binding in
- degradation in
- accumulation in
- activation in
- transactivation in
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- aggresome
- Nucleus
- basal bodies
- Mitochondria
- myofilaments
- cytosol
- nucleoplasm
- Z line
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BAG3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle cell homeostasis
- positive regulation of protein import into nucleus
- positive regulation of protein export from nucleus
- extrinsic apoptotic signaling pathway in absence of ligand
- protein folding
- induction of apoptosis via death domain receptors
- autophagic vacuole assembly
- cellular response to mechanical stimulus
- cellular response to heat
- striated muscle cell apoptotic process
- negative regulation of apoptotic process
- aggresome assembly
- cellular response to unfolded protein
- protein stabilization
- negative regulation of striated muscle cell apoptotic process
Cellular Component
Where in the cell the gene product is active
- Z disc
- nucleus
- cytoplasm
- membrane
- stress fiber
- cytosol
- aggresome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- cadherin binding
- chaperone binding
- adenyl-nucleotide exchange factor activity
- dynein intermediate chain binding