ULK1 Gene Summary [Human]
Enables identical protein binding activity; protein serine/threonine kinase activity; and small GTPase binding activity. Involved in several processes, including autophagosome assembly; positive regulation by symbiont of host autophagy; and protein phosphorylation. Located in autophagosome; cytosol; and phagophore assembly site membrane. Is extrinsic component of autophagosome membrane; extrinsic component of omegasome membrane; and extrinsic component of phagophore assembly site membrane. Part of Atg1/ULK1 kinase complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ULK1 |
| Official Name | unc-51 like autophagy activating kinase 1 [Source:HGNC Symbol;Acc:HGNC:12558] |
| Ensembl ID | ENSG00000177169 |
| Bio databases IDs | |
| Aliases | unc-51 like autophagy activating kinase 1, ATG1 autophagy related 1 homolog (S. cerevisiae) |
| Synonyms | ATG1, ATG1A, hATG1, mKIAA0722, ULK, Ulk1 mapped, UNC51, Unc51.1, unc-51 like autophagy activating kinase 1, unc-51 like kinase 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ULK1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- protein kinase binding
- Protein tyrosine and serine/threonine kinase
- heat shock protein binding
- enzyme binding
- protein binding
- Domain of unknown function (DUF3543)
- Protein kinase domain
- identical protein binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- binding protein
- Protein Kinases, catalytic domain
- serine threonine rich domain
- PDZ binding motif
- Tyrosine kinase, catalytic domain
- serine-proline rich domain
Pathways
Biological processes and signaling networks where the ULK1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- acute myeloid leukemia
- nonalcoholic fatty liver disease
- multiple sclerosis
- nonalcoholic steatohepatitis
- nonexudative age-related macular degeneration
- glioblastoma
- glioblastoma cancer
role in cell
- proliferation
- migration
- expression in
- activation in
- phosphorylation in
- apoptosis
- binding in
- autophagy
- extension
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- cytoplasmic vesicle membrane
- cellular membrane
- vesicles
- Golgi Apparatus
- cytosol
- endoplasmic reticulum membrane
- mitochondrial outer membrane
- growth cone
- neurites
- autophagic vacuoles
- recycling endosomes
- filopodia
- perikaryon
- axons
- autophagosomes
- smooth endoplasmic reticulum fraction
- rough endoplasmic reticulum fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ULK1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron projection development
- signal transduction
- negative regulation of cell proliferation
- protein localization
- response to starvation
- protein autophosphorylation
- protein phosphorylation
- mitochondrion degradation
- autophagic vacuole assembly
- positive regulation of autophagy
- negative regulation of collateral sprouting
- piecemeal microautophagy of nucleus
- cellular response to nutrient levels
- axon extension
- autophagy
- regulation of tumor necrosis factor-mediated signaling pathway
- regulation of macroautophagy
- positive regulation of autophagic vacuole assembly
- neuron projection regeneration
- negative regulation of protein complex assembly
- peptidyl-serine phosphorylation
- peptidyl-threonine phosphorylation
- macroautophagy
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- pre-autophagosomal structure membrane
- cytoplasm
- pre-autophagosomal structure
- cytosol
- recycling endosome
- mitochondrial outer membrane
- autophagic vacuole membrane
- autophagic vacuole
- axon
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein binding
- GTPase binding
- small GTPase binding
- protein serine/threonine kinase activity