TTC21A Gene Summary [Human]
Involved in flagellated sperm motility and spermatid development. Predicted to be located in cilium. Predicted to be part of intraciliary transport particle A. Implicated in spermatogenic failure 37. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TTC21A |
| Official Name | tetratricopeptide repeat domain 21A [Source:HGNC Symbol;Acc:HGNC:30761] |
| Ensembl ID | ENSG00000168026 |
| Bio databases IDs | |
| Aliases | tetratricopeptide repeat domain 21A, Stress-inducible protein 2 |
| Synonyms | 4921538N17Rik, IFT139A, RGD1308806, SPGF37, STI2, tetratricopeptide repeat domain 21A, Thm2, Ttc21a-ps1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TTC21A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tetratricopeptide repeats
- putative PEP-CTERM system TPR-repeat lipoprotein
- tetratricopeptide repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TTC21A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sperm motility
- spermatid development
- intraflagellar retrograde transport
Cellular Component
Where in the cell the gene product is active
- cilium
- intraflagellar transport particle A