STEAP3 Gene Summary [Human]
This gene encodes a multipass membrane protein that functions as an iron transporter. The encoded protein can reduce both iron (Fe3+) and copper (Cu2+) cations. This protein may mediate downstream responses to p53, including promoting apoptosis. Deficiency in this gene can cause anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Details
| Type | Protein Coding |
| Official Symbol | STEAP3 |
| Official Name | STEAP3 metalloreductase [Source:HGNC Symbol;Acc:HGNC:24592] |
| Ensembl ID | ENSG00000115107 |
| Bio databases IDs | |
| Aliases | STEAP3 metalloreductase |
| Synonyms | 1010001D01Rik, AHMIO2, dudlin-2, dudulin-2, FLJ10829, pHyde, STEAP3 metalloreductase, STEAP family member 3, STMP3, TSAP6 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human STEAP3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- FAD binding
- cupric reductase
- ferric-chelate reductase
- metal ion oxidising:NAD or NADP oxidoreductase
- NADP oxidoreductase coenzyme F420-dependent
- Cytochrome_b_N
- protein binding
- heme binding
- cytosolic tail domain
- identical protein binding
- transporter
Pathways
Biological processes and signaling networks where the STEAP3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- hepatitis B virus-related hepatocellular carcinoma
- liver cancer
- epithelial cancer
- endometrial adenocarcinoma
- endometrial adenocarcinoma formation
- lung adenocarcinoma
- lung adenocarcinoma formation
- hypochromic microcytic anemia with iron overload 2
- organismal death
role in cell
- expression in
- phosphorylation in
- apoptosis
- activation in
- number
- growth
- quantity
- migration
- abnormal morphology
- ferroptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell periphery
- Plasma Membrane
- endosomes
- endosomal membrane
- multivesicular bodies
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human STEAP3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transferrin transport
- apoptotic process
- protein secretion
- copper ion import
Cellular Component
Where in the cell the gene product is active
- endosome
- cytoplasm
- endosome membrane
- multivesicular body
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- FAD binding
- oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor
- ferric-chelate reductase (NADPH) activity
- protein binding
- metal ion binding
- cupric reductase activity
- heme binding