TRIM49 Gene Summary [Human]
The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This gene has been found to be preferentially expressed in testis. Related pseudogenes and gene duplicates have also been identified on chromosome 11. [provided by RefSeq, Aug 2010]
Details
| Type | Protein Coding |
| Official Symbol | TRIM49 |
| Official Name | tripartite motif containing 49 [Source:HGNC Symbol;Acc:HGNC:13431] |
| Ensembl ID | ENSG00000168930 |
| Bio databases IDs | |
| Aliases | tripartite motif containing 49 |
| Synonyms | RNF18, TRIM49A, TRIM49L2, tripartite motif containing 49 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRIM49 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- B-box-type zinc finger superfamily
- protein kinase binding
- SPRY domain
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- protein binding
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRIM49 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- innate immune response
- regulation of gene expression
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- zinc ion binding
- protein binding