CKS1B Gene Summary [Human]
CKS1B protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS1B mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects a specialized role for the encoded protein. At least two transcript variants have been identified for this gene, and it appears that only one of them encodes a protein. [provided by RefSeq, Sep 2008]
Details
| Type | Protein Coding |
| Official Symbol | CKS1B |
| Official Name | CDC28 protein kinase regulatory subunit 1B [Source:HGNC Symbol;Acc:HGNC:19083] |
| Ensembl ID | ENSG00000173207 |
| Bio databases IDs | |
| Aliases | CDC28 protein kinase regulatory subunit 1B |
| Synonyms | 2410005G18Rik, 2610005D03Rik, CDC28 protein kinase 1b, CDC28 protein kinase regulatory subunit 1B, CDC28 REGULATORY subunit 1B, CKS1, ckshs1, PNAS-16, PNAS-18, RGD1561797, sid1334, Sid1334p, Suc1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CKS1B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- anion binding exosite
- protein binding
- enzyme
- cyclin-dependent kinase binding domain
- Cyclin-dependent kinase regulatory subunit
Pathways
Biological processes and signaling networks where the CKS1B gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic myeloid leukemia
- cancer
- neoplasia
- squamous cell cancer
- epithelial cancer
- epithelial neoplasia
- lung adenocarcinoma
- lung adenocarcinoma formation
- hepatocellular carcinoma
- liver cancer
role in cell
- expression in
- growth
- transcription in
- proliferation
- activation in
- cell viability
- apoptosis
- senescence
- colony formation
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CKS1B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fibroblast proliferation
- cell division
- regulation of transcription, DNA-dependent
- regulation of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- cyclin-dependent protein kinase holoenzyme complex
- SCF ubiquitin ligase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- ubiquitin binding
- histone binding